Scientific opinion on safety and suitability for infant use in accordance with – for a prescription with a protein content of at least 1.6 g/100 kcal This publication is linked to the following EFSA support publication article. http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2017.EN-1215/fullefsa.onlinelibrary.wiley.com Scientific opinion on safety and suitability for infant use in accordance with – for a prescription with a protein content of at least 1.6 g/100 kcal. This publication is linked to the following EFSA support publication article. http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2017.EN-1215/fullefsa.onlinelibrary.wiley.com
On the other hand, the safety of hydrolyzed proteins and soybean protein isolates in the same proportion is not concluded due to lack of data. I have taken a reserved stance, and although IARC is an international cancer research institution, it is not currently cancer-causing or has not been verified because it does not appear on the list. 3. Hydrolytic proteins are intermediate in the dangerous food additives of hydrolytic proteins, but there are no standards or regulations for use, and some studies have pointed out the dangers of hydrolytic proteins. 1. Exposure of new antigens If the protein structure is changed by hydrolysis, the specific molecular structure (epitope) that causes an allergic reaction may be exposed to the outside and may become a completely different antigen than before. There have been reports that the number of reports of hypersensitivity in people, including severe systemic reactions (anaphylactic shocks), has increased since products containing high levels of hydrolysis began to enter the market. (https://www.vetsmall.theclinics.com/article/S0195-5616(06)00099-4/fulltext) For the same reason, if hydrolytic proteins are used as raw materials for pet food, there is no denying the possibility of allergies caused by antigens accidentally exposed during the decomposition process. In fact, in a review of hydrolytic protein breeding tests, there are reports that symptoms have worsened in some dogs. <Article Link> On the other hand, the safety of hydrolyzed proteins and soybean protein isolates in the same proportion was not concluded due to lack of data. I have taken a reserved stance, and although IARC is an international cancer research institution, it is not currently cancer-causing or has not been verified because it does not appear on the list. 3. Hydrolytic proteins are intermediate in the dangerous food additives of hydrolytic proteins, but there are no standards or regulations for use, and some studies have pointed out the dangers of hydrolytic proteins. 1. Exposure of new antigens If the protein structure is changed by hydrolysis, the specific molecular structure (epitope) that causes an allergic reaction may be exposed to the outside and may become a completely different antigen than before. There have been reports that the number of reports of hypersensitivity in people, including severe systemic reactions (anaphylactic shocks), has increased since products containing high levels of hydrolysis began to enter the market. (https://www.vetsmall.theclinics.com/article/S0195-5616(06)00099-4/fulltext) For the same reason, if hydrolytic proteins are used as raw materials for pet food, there is no denying the possibility of allergies caused by antigens accidentally exposed during the decomposition process. In fact, in a review of hydrolytic protein breeding tests, there are reports that symptoms have worsened in some dogs. < Article Link>
Systematic review of evidence of reduced food hydrolysates and clinical benefits in dogs with skin-hazardous food reactions Some hydrolysate-based diets are commercialized to help diagnose or treat dogs with skin side effects (CAFR). This systematic review was conducted to investigate evidence from the online library. wiley.com Systematic review of evidence of reduced food hydrolysates and clinical benefits in dogs with skin-hazardous food reactions Some hydrolysate-based diets are commercialized to help diagnose or treat dogs with skin side effects (CAFR). This systematic review was conducted to investigate evidence from the online library. wiley.com
2. If the protein structure is changed by the singer decomposition of the antigen remaining, the specific molecular structure (epitope) that causes the allergic reaction will be destroyed, and the allergy will not occur as a result. However, it has been shown that the decomposition process is insufficient and the molecular weight increases and the antigen may remain. As an example of Japanese people, cosmetics using hydrolyzed wheat protein are famous. Around 2010, there were a series of cases of allergic reactions caused by the use of soap containing hydrolyzed wheat. As a result of investigating the product that caused the accident, the correlation between the molecular weight distribution of wheat protein and the degree of amino acid change and the risk of allergic development was revealed. After that, the quality of hydrolyzed wheat was determined by revising the “Simple Pharmaceutical Ingredient Standard 2006”. <Article Link> 2. If the protein structure is changed by the singer decomposition of the antigen remaining, the specific molecular structure (epitope) that causes the allergic reaction will be destroyed, resulting in no allergies. However, it has been shown that the decomposition process is insufficient and the molecular weight increases and the antigen may remain. As an example of Japanese people, cosmetics using hydrolyzed wheat protein are famous. Around 2010, there were a series of cases of allergic reactions caused by the use of soap containing hydrolyzed wheat. As a result of investigating the product that caused the accident, the correlation between the molecular weight distribution of wheat protein and the degree of amino acid change and the risk of allergic development was revealed. After that, the quality of hydrolyzed wheat was determined by revising the “Simple Pharmaceutical Ingredient Standard 2006”. < Article Link>
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Hydrolyzed Proteins | Biotechnology | Product Evaluation Technology-based Instruments Protein hydrolysates from products containing wheat hydrolysates are widely used in non-pharmaceutical products and cosmetics such as shampoo and soap for better moisturization and lathering. By using soap containing hydrolyzed bear in around 2010, it was found that there were many cases of wheat allergy. Most of them are facial skin disorders, but there were also many serious cases of anaphylactic shock such as shortness of breath or loss of consciousness. Due to the high risk and the high number of soap sold, the potential victims are expected to be a large number of people, so on October 15, 2010, the Ministry of Health, Labor and Welfare announced that ‘Medicine containing wheat hydrolysates…www.nite.go.jp ‘
Pet food is not safe, either. In Japan, we highlighted “that allergen” and analyzed two commercially available feedstocks and found that the product contained a fairly large peptide which ranged in molecular weight from 1.5 to 3.5 kDa. We also contacted 316 individuals in the peripheral blood of dogs with food hypersensitivity to food and found that T-cell activation was 28.8% (91/316) in Company A’s product and 23.7% (75/316) in Company B’s product. The findings indicate that the feedstocks have low allergies, but they warn that it contains peptides of the size that trigger an immune response and that they are not necessarily effective Pet food is not safe, either. In Japan, we highlighted “that allergen” and analyzed two commercially available feedstocks and found that the product contained a fairly large peptide which ranged in molecular weight from 1.5 to 3.5 kDa. We also contacted 316 individuals in the peripheral blood of dogs with food hypersensitivity to food and found that T-cell activation was 28.8% (91/316) in Company A’s product and 23.7% (75/316) in Company B’s product. The findings indicate that the feedstocks have low allergies, but they warn that it contains peptides of the size that trigger an immune response and that they are not necessarily effective
Hydrolyzed diets can stimulate dog food reactive lymphocytes. Hydrolyzed proteins are often prescribed to dogs with food hypersensitivity in food removal programs. However, the potential of these diets is …www.jstage.jst.go.jp Hydrolyzed diets can stimulate dog food reactive lymphocytes. Hydrolyzed proteins are often prescribed to dogs with food hypersensitivity in food removal programs. However, the potential of these diets is … www.jstage.jst.go.jp
건조하고 습한 소설 및 마이크로어레이 분석으로 탐지된 개와 고양이를 위한 가수분해 단백질 식단의 미신고 동물 종 – BMC 수의학 연구 배경 유럽 반려동물 식품 산업 연맹(FEDIAF)은 라벨이 정확하고 성분에 대한 자세한 정보를 제공해야 한다고 밝혔지만, 반려동물 사료의 잘못된 라벨링은 여러 저자에 의해 문서화되었습니다. 이러한 현상은 엘…bmcvetres.biomedcentral.com 로 사용되는 제품과 관련하여 특히 우려되는 사항입니다 건조하고 습한 소설 및 마이크로어레이 분석으로 탐지된 개와 고양이를 위한 가수분해 단백질 식단의 미신고 동물 종 – BMC 수의학 연구 배경 유럽 반려동물 식품 산업 연맹(FEDIAF)은 라벨이 정확하고 성분에 대한 자세한 정보를 제공해야 한다고 밝혔지만, 반려동물 사료의 잘못된 라벨링은 여러 저자에 의해 문서화되었습니다. 이러한 현상은 엘…bmcvetres.biomedcentral.com 로 사용되는 제품과 관련하여 특히 우려되는 사항입니다
“수산화물”는 무엇인가?Q&A는 “수산화물”는 무엇입니까?Q&A는 2009년 4월 7일, 2003 ●는 단백질 수산화물 수산화물입니다.Q&AQ1: “음”: “수산화물”는 종종 어떤가?안전성에 대해 걱정돼요.Q2: 수산화물 분석가?Q3: 안전점점은 무엇입니까?Q4: 사용 목적은 무엇입니까?Q1가지 음식은 종종 “수화”로 표시됩니까?안전성에 대해 걱정돼요.1 단백질 수산화물은 밀과 고기로부터 만들어진 종류의 음식이다.주로 다양한 아미노산으로부터 만들어지고 가공식품에 따라 양념된 음식들을 위해 사용된다. jccu.coop “에 따르면, “음식… jccu.coop”고 말했다.
자발성 식품 알레르기가 있는 개의 옥수수 전분, 옥수수, 대두 및 대두 가수분해물 식이요법에 대한 경구 투여에 대한 임상 및 알레르겐 특이적 혈청 면역글로불린 E 반응 평가추출물 대두와 옥수수에 대한 임상적 과민성이 알려진 14마리의 개를 소양증의 피부 증상이 최소화될 때까지 제한된 항원 오리 및 쌀 식이요법으로 유지했습니다(78일)….onlinelibrary.wiley.com 자발성 식품 알레르기가 있는 개의 옥수수 전분, 옥수수, 대두 및 대두 가수분해물 식이요법에 대한 경구 투여에 대한 임상 및 알레르겐 특이적 혈청 면역글로불린 E 반응 평가추출물 대두와 옥수수에 대한 임상적 과민성이 알려진 14마리의 개를 소양증의 피부 증상이 최소화될 때까지 제한된 항원 오리 및 쌀 식이요법으로 유지했습니다(78일)….onlinelibrary.wiley.com
2. Some studies have suggested the possibility of hydrolyzed proteins for inflammatory bowel disease (IBD). For more information, see PDF file at the address below: pro.dermavet.com/wp-content/uploads/clients/purina/Marks_et_al._2004-hydrolysed_diet_in_dogs_with_IBD.pdf3 . For dietary allergies, there are studies showing that using hydrolyzed proteins does not cause allergic reactions. For more information, please click the link below. 2. Some studies have suggested the possibility of hydrolyzed proteins for inflammatory bowel disease (IBD). For more information, see PDF file at the address below: pro.dermavet.com/wp-content/uploads/clients/purina/Marks_et_al._2004-hydrolysed_diet_in_dogs_with_IBD.pdf3 . For dietary allergies, there are studies showing that using hydrolyzed proteins does not cause allergic reactions. For more information, please click the link below.
실험적으로 유도된 대두 과민증을 가진 개의 가수분해된 대두 단백질에 대한 면역학적 반응 추상적 목표-콩 단백질에 대한 실험적으로 유도된 I형 과민증을 가진 개가 대두 가수분해물에 반응하여 피내 및 경구 챌린지 노출 후 피부 또는 위장관 반응을 일으킬지 여부를 평가합니다. 동물 – 순진한 비글 강아지 12마리(감작 9마리, 감작 3마리…avmajournals.avma.org ) 실험적으로 유도된 대두 과민증을 가진 개의 가수분해된 대두 단백질에 대한 면역학적 반응 추상적 목표-콩 단백질에 대한 실험적으로 유도된 I형 과민증을 가진 개가 대두 가수분해물에 반응하여 피내 및 경구 챌린지 노출 후 피부 또는 위장관 반응을 일으킬지 여부를 평가합니다. 동물 – 순진한 비글 강아지 12마리(감작 9마리, 감작 3마리…avmajournals.avma.org )
4. Chronic bowel disease A research team at Utrecht University in the Netherlands has also found that studies using hydrolytic proteins for chronic bowel disease in dogs have reduced symptoms. 4. Chronic bowel disease A research team at Utrecht University in the Netherlands has also found that studies using hydrolytic proteins for chronic bowel disease in dogs have reduced symptoms.
만성 소장 장병증이 있는 개를 대상으로 한 가수분해 단백질 식단에 대한 무작위 개방형 ‐ 라벨, 양성 ‐ 대조 현장 시험 배경: 가수분해 단백질 식단은 일반적으로 개 만성 장병증(CE)을 관리하는 데 사용되지만 아직 그 효능이 비판적으로 평가되지 않았습니다. 가설: 가수분해 단백질 식단 i…onlinelibrary.wiley.com 만성 소장 장병증이 있는 개를 대상으로 한 가수분해 단백질 식단에 대한 무작위 개방형 ‐ 라벨, 양성 ‐ 대조 현장 시험 배경: 가수분해 단백질 식단은 일반적으로 개 만성 장병증(CE)을 관리하는 데 사용되지만 아직 그 효능이 비판적으로 평가되지 않았습니다. 가설: 가수분해 단백질 식단 i…onlinelibrary.wiley.com
Hydrolytic proteins have two sides. Feed manufacturers say that hydrolytic proteins are helpful for allergies by citing only the advantages of hydrolytic protein research. Because hydrolytic proteins have a different structure from the original protein molecules, the current hydrolytic proteins are not known exactly about their safety and risks in the long run. I’m going to rearrange them. Hydrolytic proteins have two sides. Feed manufacturers say that hydrolytic proteins are helpful for allergies by citing only the advantages of hydrolytic protein research. Because hydrolytic proteins have a different structure from the original protein molecules, the current hydrolytic proteins are not known exactly about their safety and risks in the long run. I’m going to rearrange them.